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TCES seminar series -November

“Modular PEG hydrogels for organoid-based disease modelling” seminar by Dr Eileen Gentleman, King’s College, London

About this Event

Due to the success of our virtual seminar series over the summer, we have decided to continue them each month.

The first seminar will be on Thursday 19th November from 1130-1215 and will feature Dr Eileen Gentleman from King’s College.

The abstract is below and the link to join is: https://eu.bbcollab.com/guest/9d08cfa20c8442b39a08303020194a8b

This seminar is hosted by the University of Southampton.

Please register on this Eventbrite page.

https://www.eventbrite.co.uk/e/tces-virtual-seminar-series-dr-eileen-gentleman-seminar-tickets-126101754743

An abstract is below.

Best wishes

The TCES committee.

Modular PEG hydrogels for organoid-based disease modelling

Dr Eileen Gentleman, King’s College, London

Thursday 19th November 2020, 1130am

Pathological matrix remodelling plays a central role in many human diseases, but is challenging to study as in vitro models often cannot replicate the complex 3D cell-matrix interactions that drive pathologies. In this seminar, I will discuss how we built a 3D model of the human gut that allowed us to uncover an unexpected role for a rare immune cell type called ILC1 in driving gut fibrosis in patients with inflammatory bowel diseases. We used molecular dynamics simulations to design PEG hydrogels that cross-link quickly, but can still mimic the stiffness of normal intestinal tissue. We then co-cultured encapsulated human intestinal organoids with ILC1, and using a combination of atomic force microscopy force spectroscopy and multiple particle tracking microrheology, found that ILC1 drive intestinal matrix remodelling through a balance of MMP9-mediated matrix degradation and TGFβ1-driven fibronectin deposition. Our findings demonstrate the potential of using hydrogels in disease modelling, and open the possibility of unravelling how pathological matrix remodelling contributes to disease.

Eileen Gentleman is a Senior Research Fellow and Principal Investigator in the Centre for Craniofacial and Regenerative Biology at King’s College London.

She joined Imperial College London in 2005 as post-doctoral research associate (Stevens Group) after completing her PhD in Biomedical Engineering (Tulane University, USA). In 2011, she was awarded a Wellcome Trust Research Career Development Fellowship and moved to King’s where her research focuses on developing biomaterials to modulate the physical and biological properties of the 3D cell niche to control stem cell differentiation for tissue engineering. Her work has been published in Nature Materials, Proceedings of the National Academy of Sciences USA, and Biomaterials.

Eileen has received funding awards from the Wellcome Trust, the Rosetrees Trust, the Royal Society and Orthopaedic Research UK, and is a recipient of both a Wellcome Image Award (2016) and an MIT Koch Institute Image Award (2016). The Orthopaedic Research Society named her as a finalist for their New Investigator Recognition Award (2010) and in 2013 her work in regenerative medicine was recognised with a prestigious Philip Leverhulme Prize.

CITER Annual Scientific Meeting 2020 –

Dear Colleagues,

On behalf of the Cardiff Institute of Tissue Engineering and Repair (CITER) Research Committee I am pleased to notify you of details for this year’s CITER Annual Scientific Meeting 2020. The two-day meeting is taking place between 14th – 15th September and is being held online. Please note there will be no fee to attend this meeting.

The Programme comprises of six sessions over the two days and four research themes including:

·        Immunology, Infection and Inflammation;

·        Applied Healthcare Technology;

·        Mind, Brain and Neurosciences;

·        Cancer

There are four keynote speakers relevant to each aforementioned theme, invited guest speakers and talks from our bursary awardees on how the CITER funding has allowed for collaborations of an interdisciplinary nature and any future work.

Our keynote speakers are:

·        Professor Yamni Nigam, Swansea University

·        Professor Philip Rowe, University of Strathclyde

·        Dr Zameel Cader, University of Oxford

·        Professor Xin Lu, University of Oxford

The meeting provides an excellent means of encouraging the participation of academic staff and students to present their research in either a poster or delivering a talk in a supportive but critical environment which helps your career development. In addition, the meeting provides an excellent opportunity for students and early stage researchers to Chair academic sessions.

To book your space please register via Eventbrite https://www.eventbrite.com/e/citer-annual-scientific-meeting-2020-online-tickets-90931106387

Additional details attached.  If you have any queries please email al-amrim@cardiff.ac.uk

Join us for Virtual TCES 2020!

It has been a difficult year for scientific conferences and unfortunately we have been unable to arrange a ‘physical’ meeting this year

But in response to this, the TCES committee have decided to host a series of virtual seminars showcasing the research originally planned for our TCES day of TERMIS EU. We would like to invite you to join these virtual seminars beginning on June 18th. Seminars will be held online at 10am BST on Thursdays and will feature talks from those originally scheduled to speak at the TCES days of TERMIS EU. To register your interest in attending and to receive the webinar links ahead of the seminars please enter your details here.

Please direct any emails about the seminar series to conference@tces.org

Neurospheres attached on biological material (PDL/Laminin) coated glass coverslip

Research fellow position available at UCL

This project aims to develop a therapeutic bio-scaffold that may be applied following neurosurgical intervention, to deliver stem cells in the early treatment of Traumatic Brain Injury (TBI).  

It is a collaboration project between the groups of James Phillips (UCL Centre for Nerve Engineering), Aminul Ahmed (UCL Institute of Neurology) and Molly Stevens (Imprerial College London).  

The Research Fellow will lead the in vivo testing of novel cellular biomaterials for use in treating TBI.  

The post is available from 1 March 2020 until 30 November 2020 in the first instance. 

An understanding of translational aspects of regenerative medicine, in particular Advanced Therapy Medicinal Product development for nervous system applications. Enthusiasm for interdisciplinary translational research collaboration and familiarity with the use of in vivo models are required.  

Applicants should apply online. To access further details about the position and how to apply please click on the ‘Apply’ button above. 

If you have any queries regarding the vacancy or the application process, please contact Heather Badru Staffing and HR Officer, (sop.hr@ucl.ac.uk). 

The UCL Ways of Working for professional services supports colleagues to be successful and happy at UCL through sharing expectations around how we work – please see www.ucl.ac.uk/ways-of-working to find out more. 

Latest time for the submission of applications: 23:59.

TCES Net meeting, Winter 2020

We are delighted to invite you to the launch of the UCL Centre for 3D models of health and disease.

The Centre for 3D models of health and disease focuses on developing biomimetic tissue models to study fundamental tissue biology and the impact of disease progression on tissue form and function. We bio-engineer advanced tissue models and cover a range of tissues from skeletal muscle to tendon and skin. The centre also works on biomimetic models of cancer, which we term tumouroids, engineering distinct cancer masses within complex stromal compartments to study cancer invasion and metastasis. These models have been used to interrogate the actions of chemotherapeutic drugs and other therapeutic modalities.

The event will be held at Charles Bell House (UCL) in 43-45 Foley Street, London (W1W 7TS) on the 20th January 2020 from 11am to 3pm.

Please register here

The meeting is kindly funded by TCES Net and Lonza.

We look forward to welcoming you.

Meeting announcement: Mercia Stem Cell Alliance (MSCA) Meeting, December 17th

The Mercia Stem Cell Alliance nucleates notable regional Centres of Excellence supporting the translation of innovative basic stem cell research to effective therapies. By harnessing the expertise of its members, the Alliance aims to facilitate the essential development and promotion of stem cell research in the region.

At the MSCA Annual Conference, more than 150 delegates from all over the nation discuss and present the state of the art of their research.  This year, the Annual Conference will take place on December 17th at the University of Chester and will be chaired by Prof. Eustace Johnson from Chester Medical School. The main conference will feature guest speakers Professor Matthew Dalby (Glasgow) and Professor Uri Frank (NUI Galway).

The Conference will be preceded by a Young Investigators Workshop on ‘extracellular vesicles and the wider cell secretome’, on December 16th, which will provide lectures and practical demonstrations on cutting-edge methods and developments in the area, and how they can be applied for stem cell research. A poster with further information on speakers presenting at the event is attached.

Information on how to register for the meeting can be found here: https://storefront.chester.ac.uk/index.php?main_page=product_info&products_id=701

MSCA Conference 2019 Flyer (2)